Ontology highlight
ABSTRACT:
SUBMITTER: Bauer K
PROVIDER: S-EPMC4559678 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Bauer Kristen K Esquilin Ines O IO Cornier Alberto Santiago AS Thomas Stephen J SJ Quintero Del Rio Ana I AI Bertran-Pasarell Jorge J Morales Ramirez Javier O JO Diaz Clemente C Carlo Simon S Eckels Kenneth H KH Tournay Elodie E Toussaint Jean-Francois JF De La Barrera Rafael R Fernandez Stefan S Lyons Arthur A Sun Wellington W Innis Bruce L BL
The American journal of tropical medicine and hygiene 20150714 3
This was a double-blind, randomized, controlled, phase II clinical trial, two dose study of re-derived, live-attenuated, tetravalent dengue virus (TDEN) vaccine (two formulations) or placebo in subjects 1-50 years of age. Among the 636 subjects enrolled, 331 (52%) were primed, that is, baseline seropositive to at least one dengue virus (DENV) type. Baseline seropositivity prevalence increased with age (10% [< 2 years], 26% [2-4 years], 60% [5-20 years], and 93% [21-50 years]). Safety profiles of ...[more]