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Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells.

ABSTRACT: Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.

SUBMITTER: Pan YT

PROVIDER: S-EPMC4560650 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells.

Pan Yung-Tin YT Smith Cartney E CE Kwok Kam Sang KS Chen Jinrong J Kong Hyunjoon H Yang Hong H

Chemical communications (Cambridge, England) 20150812 75

Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% ...[more]

PMID: 26264283

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