A simplified spin and gradient echo approach for brain tumor perfusion imaging.

ABSTRACT:

Purpose

In this study, we propose a simplified acquisition and analysis approach for spin and gradient echo (SAGE)-based dynamic susceptibility-contrast MRI (DSC-MRI) data that is free of contrast agent T1 leakage effects.

Methods

A five-echo SAGE sequence was used to acquire DSC-MRI data in rat C6 tumors (n = 7). Nonlinear fitting of all echoes was performed to obtain T1-insensitive ΔR2* and ΔR2 time series. The simplified approach, which includes two gradient echoes and one spin echo, was also used to analytically compute T1-insensitive ΔR2* using the two gradient echoes and ΔR2 using all three echoes. The blood flow, blood volume, and vessel size values derived from each method were compared.

Results

In all cases, the five-echo and simplified SAGE ΔR2* and ΔR2 were

SUBMITTER: Stokes AM 

PROVIDER: S-EPMC4561038 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature