Ontology highlight
ABSTRACT:
SUBMITTER: Andrade BB
PROVIDER: S-EPMC4561190 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Andrade Bruno B BB Pavan Kumar Nathella N Amaral Eduardo P EP Riteau Nicolas N Mayer-Barber Katrin D KD Tosh Kevin W KW Maier Nolan N Conceição Elisabete L EL Kubler Andre A Sridhar Rathinam R Banurekha Vaithilingam V VV Jawahar Mohideen S MS Barbosa Theolis T Manganiello Vincent C VC Moss Joel J Fontana Joseph R JR Marciano Beatriz E BE Sampaio Elizabeth P EP Olivier Kenneth N KN Holland Steven M SM Jackson Sharon H SH Moayeri Mahtab M Leppla Stephen S Sereti Irini I Barber Daniel L DL Nutman Thomas B TB Babu Subash S Sher Alan A
Journal of immunology (Baltimore, Md. : 1950) 20150812 6
Pulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the implications for TB diagnosis and disease staging are poorly understood. Heme oxygenase-1 (HO-1) levels were previously shown to distinguish active from latent TB, as well as successfully treated Mycobacterium tuberculosis infection. MMP-1 expression is also associated with active TB. In this study, w ...[more]