Ontology highlight
ABSTRACT:
SUBMITTER: Hansen P
PROVIDER: S-EPMC4561497 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Hansen Peter P Hecht Jochen J Ibrahim Daniel M DM Krannich Alexander A Truss Matthias M Robinson Peter N PN
Genome research 20150710 9
Chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq) is a powerful technology to identify the genome-wide locations of transcription factors and other DNA binding proteins. Computational ChIP-seq peak calling infers the location of protein-DNA interactions based on various measures of enrichment of sequence reads. In this work, we introduce an algorithm, Q, that uses an assessment of the quadratic enrichment of reads to center candidate peaks followed by statistical a ...[more]