Ontology highlight
ABSTRACT:
SUBMITTER: Verma V
PROVIDER: S-EPMC4562706 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Verma Vikash V Mallik Leena L Hariadi Rizal F RF Sivaramakrishnan Sivaraj S Skiniotis Georgios G Joglekar Ajit P AP
PloS one 20150908 9
DNA origami provides a versatile platform for conducting 'architecture-function' analysis to determine how the nanoscale organization of multiple copies of a protein component within a multi-protein machine affects its overall function. Such analysis requires that the copy number of protein molecules bound to the origami scaffold exactly matches the desired number, and that it is uniform over an entire scaffold population. This requirement is challenging to satisfy for origami scaffolds with man ...[more]