Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.
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ABSTRACT:
SUBMITTER: Solman M
PROVIDER: S-EPMC4563131 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.
Šolman Maja M Ligabue Alessio A Blaževitš Olga O Jaiswal Alok A Zhou Yong Y Liang Hong H Lectez Benoit B Kopra Kari K Guzmán Camilo C Härmä Harri H Hancock John F JF Aittokallio Tero T Abankwa Daniel D
eLife 20150814
Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. Here, we show that several cancer-associated mutations in the switch III region moderately increase Ras activity in all isoforms. Mutants are biochemically inconspicuous, while their clustering into nanoscale signaling complexes on the plasma membrane, ...[more]
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