Regulatory microRNA networks: complex patterns of target pathways for disease-related and housekeeping microRNAs.

ABSTRACT: Blood-based microRNA (miRNA) signatures as biomarkers have been reported for various pathologies, including cancer, neurological disorders, cardiovascular diseases, and also infections. The regulatory mechanism behind respective miRNA patterns is only partially understood. Moreover, "preserved" miRNAs, i.e., miRNAs that are not dysregulated in any disease, and their biological impact have been explored to a very limited extent. We set out to systematically determine their role in regulatory networks by defining groups of highly-dysregulated miRNAs that contribute to a disease signature as opposed to preserved housekeeping miRNAs. We further determined preferential targets and pathways of both dysregulated and preserved miRNAs by computing multi-layer networks, which were compared between h

SUBMITTER: Zafari S 

PROVIDER: S-EPMC4563351 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature