Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse.
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ABSTRACT:
SUBMITTER: Tian R
PROVIDER: S-EPMC7137714 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse.
Tian Rui R Zou He H Wang Lu-Fei LF Song Mei-Jiao MJ Liu Lu L Zhang Hui H
International journal of ophthalmology 20200418 4
<h4>Aim</h4>To explore the mRNA and pathways related to retinoblastoma (RB) genesis and development.<h4>Methods</h4>Microarray datasets GSE29683 (human) and GSE29685 (mouse) were downloaded from NCBI GEO database. Homologous genes between the two species were identified using WGCNA, followed by protein-protein interaction (PPI) network construction and gene enrichment analysis. Disease-related miRNAs and pathways were retrieved from miR2Disease database and Comparative Toxicogenomics Database (C ...[more]
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