Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
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ABSTRACT:
SUBMITTER: Kim MS
PROVIDER: S-EPMC4564120 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
Kim Min Soo MS Yan Jingqi J Wu Wenhe W Zhang Guo G Zhang Yalin Y Cai Dongsheng D
Nature immunology 20150406 5
Innate immunological signals induced by pathogen- and/or damage-associated molecular patterns are essential for adaptive immune responses, but it is unclear if the brain has a role in this process. Here we found that while the abundance of tumor-necrosis factor (TNF) quickly increased in the brain of mice following bacterial infection, intra-brain delivery of TNF mimicked bacterial infection to rapidly increase the number of peripheral lymphocytes, especially in the spleen and fat. Studies of va ...[more]
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