Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin PJ
PROVIDER: S-EPMC4565534 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Goodwin Pamela J PJ Parulekar Wendy R WR Gelmon Karen A KA Shepherd Lois E LE Ligibel Jennifer A JA Hershman Dawn L DL Rastogi Priya P Mayer Ingrid A IA Hobday Timothy J TJ Lemieux Julie J Thompson Alastair M AM Pritchard Kathleen I KI Whelan Timothy J TJ Mukherjee Som D SD Chalchal Haji I HI Oja Conrad D CD Tonkin Katia S KS Bernstein Vanessa V Chen Bingshu E BE Stambolic Vuk V
Journal of the National Cancer Institute 20150304 3
<h4>Background</h4>Metformin may improve metabolic factors (insulin, glucose, leptin, highly sensitive C-reactive protein [hs-CRP]) associated with poor breast cancer outcomes. The NCIC Clinical Trials Group (NCIC CTG) MA.32 investigates effects of metformin vs placebo on invasive disease-free survival and other outcomes in early breast cancer. Maintaining blinding of investigators to outcomes, we conducted a planned, Data Safety Monitoring Committee-approved, analysis of the effect of metformin ...[more]