Ontology highlight
ABSTRACT:
SUBMITTER: Lohmann AE
PROVIDER: S-EPMC5798974 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lohmann Ana Elisa AE Liebman Mira F MF Brien William W Parulekar Wendy R WR Gelmon Karen A KA Shepherd Lois E LE Ligibel Jennifer A JA Hershman Dawn L DL Rastogi Priya P Mayer Ingrid A IA Hobday Timothy J TJ Lemieux Julie J Thompson Alastair Mark AM Pritchard Kathleen I KI Whelan Timothy Joseph TJ Mukherjee Som D SD Chalchal Haji I HI Bernstein Vanessa V Stambolic Vuk V Chen Bingshu E BE Goodwin Pamela Jean PJ
Breast cancer research and treatment 20170426 2
<h4>Background</h4>Metformin is associated with low levels of vitamin B12 (VitB12) in patients with diabetes. The CCTG/MA.32 trial investigates the effects of metformin vs placebo on breast cancer (BC) outcomes in non-diabetic high-risk BC patients. We analyzed VitB12 at baseline and after 6 months of metformin (versus placebo) in the first 492 patients with paired blood samples.<h4>Methods</h4>VitB12 was analyzed centrally in baseline and 6-month fasting plasma. Levels <181 pmol/L were consider ...[more]