Ontology highlight
ABSTRACT:
SUBMITTER: Huffman JE
PROVIDER: S-EPMC4566813 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Huffman Jennifer E JE de Vries Paul S PS Morrison Alanna C AC Sabater-Lleal Maria M Kacprowski Tim T Auer Paul L PL Brody Jennifer A JA Chasman Daniel I DI Chen Ming-Huei MH Chen Ming-Huei MH Guo Xiuqing X Lin Li-An LA Marioni Riccardo E RE Müller-Nurasyid Martina M Yanek Lisa R LR Pankratz Nathan N Grove Megan L ML de Maat Moniek P M MP Cushman Mary M Wiggins Kerri L KL Qi Lihong L Sennblad Bengt B Harris Sarah E SE Polasek Ozren O Riess Helene H Rivadeneira Fernando F Rose Lynda M LM Goel Anuj A Taylor Kent D KD Teumer Alexander A Uitterlinden André G AG Vaidya Dhananjay D Yao Jie J Tang Weihong W Levy Daniel D Waldenberger Melanie M Becker Diane M DM Folsom Aaron R AR Giulianini Franco F Greinacher Andreas A Hofman Albert A Huang Chiang-Ching CC Kooperberg Charles C Silveira Angela A Starr John M JM Strauch Konstantin K Strawbridge Rona J RJ Wright Alan F AF McKnight Barbara B Franco Oscar H OH Zakai Neil N Mathias Rasika A RA Psaty Bruce M BM Ridker Paul M PM Tofler Geoffrey H GH Völker Uwe U Watkins Hugh H Fornage Myriam M Hamsten Anders A Deary Ian J IJ Boerwinkle Eric E Koenig Wolfgang W Rotter Jerome I JI Hayward Caroline C Dehghan Abbas A Reiner Alex P AP O'Donnell Christopher J CJ Smith Nicholas L NL
Blood 20150623 11
Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and <0.05) and rare (MAF <0.01) variants that influence plasma concentrati ...[more]