The impact of low-frequency and rare variants on lipid levels.
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ABSTRACT:
SUBMITTER: Surakka I
PROVIDER: S-EPMC4757735 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
The impact of low-frequency and rare variants on lipid levels.
Surakka Ida I Horikoshi Momoko M Mägi Reedik R Sarin Antti-Pekka AP Mahajan Anubha A Lagou Vasiliki V Marullo Letizia L Ferreira Teresa T Miraglio Benjamin B Timonen Sanna S Kettunen Johannes J Pirinen Matti M Karjalainen Juha J Thorleifsson Gudmar G Hägg Sara S Hottenga Jouke-Jan JJ Isaacs Aaron A Ladenvall Claes C Beekman Marian M Esko Tõnu T Ried Janina S JS Nelson Christopher P CP Willenborg Christina C Gustafsson Stefan S Westra Harm-Jan HJ Blades Matthew M de Craen Anton J M AJ de Geus Eco J EJ Deelen Joris J Grallert Harald H Hamsten Anders A Havulinna Aki S AS Hengstenberg Christian C Houwing-Duistermaat Jeanine J JJ Hyppönen Elina E Karssen Lennart C LC Lehtimäki Terho T Lyssenko Valeriya V Magnusson Patrik K E PK Mihailov Evelin E Müller-Nurasyid Martina M Mpindi John-Patrick JP Pedersen Nancy L NL Penninx Brenda W J H BW Perola Markus M Pers Tune H TH Peters Annette A Rung Johan J Smit Johannes H JH Steinthorsdottir Valgerdur V Tobin Martin D MD Tsernikova Natalia N van Leeuwen Elisabeth M EM Viikari Jorma S JS Willems Sara M SM Willemsen Gonneke G Schunkert Heribert H Erdmann Jeanette J Samani Nilesh J NJ Kaprio Jaakko J Lind Lars L Gieger Christian C Metspalu Andres A Slagboom P Eline PE Groop Leif L van Duijn Cornelia M CM Eriksson Johan G JG Jula Antti A Salomaa Veikko V Boomsma Dorret I DI Power Christine C Raitakari Olli T OT Ingelsson Erik E Järvelin Marjo-Riitta MR Thorsteinsdottir Unnur U Franke Lude L Ikonen Elina E Kallioniemi Olli O Pietiäinen Vilja V Lindgren Cecilia M CM Stefansson Kari K Palotie Aarno A McCarthy Mark I MI Morris Andrew P AP Prokopenko Inga I Ripatti Samuli S
Nature genetics 20150511 6
Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, including 79 previously identified loci with new lead SNPs and 10 new loci, 15 loci with a low-frequency lead SNP and 10 loci with a missense lead SNP, and 2 loci with an accumulation of rare variants. In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutat ...[more]
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