Ontology highlight
ABSTRACT:
SUBMITTER: Patsch C
PROVIDER: S-EPMC4566857 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nature cell biology 20150727 8
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types. Here, we report the rapid and efficient differentiation of human pluripotent stem cells into vascular endothelial and smooth muscle cells. We found that GSK3 inhibition and BMP4 treatment rapidly committed pluripotent cells to a mesodermal fate and subsequent exposure to VEGF-A or PDGF-BB resulted in the differentiation of ei ...[more]