Ontology highlight
ABSTRACT:
SUBMITTER: Williams IM
PROVIDER: S-EPMC6597190 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Williams Ian M IM Wu Joseph C JC
Arteriosclerosis, thrombosis, and vascular biology 20190509 7
Endothelial cells (ECs) are critical for several aspects of cardiovascular disease therapy, including vascular regeneration, personalized drug development, and tissue engineering. Human pluripotent stem cells (hPSCs) afford us with an unprecedented opportunity to produce virtually unlimited quantities of human ECs. In this review, we highlight key developments and outstanding challenges in our ability to derive ECs de novo from hPSCs. Furthermore, we consider strategies for recapitulating the ve ...[more]