Ontology highlight
ABSTRACT:
SUBMITTER: Gulati S
PROVIDER: S-EPMC4567697 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Gulati Sonia S Ekland Eric H EH Ruggles Kelly V KV Chan Robin B RB Jayabalasingham Bamini B Zhou Bowen B Mantel Pierre-Yves PY Lee Marcus C S MC Spottiswoode Natasha N Coburn-Flynn Olivia O Hjelmqvist Daisy D Worgall Tilla S TS Marti Matthias M Di Paolo Gilbert G Fidock David A DA
Cell host & microbe 20150901 3
During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids. Consistent with this essential role, Plasmodium lipid synthesis enzymes are emerging as potential drug targets. To explore their broader potential for therapeutic interventions, we assayed the global lipid landscape during P. falciparum sexual and asexual blood stage (ABS) development. Using liquid chromatography-mass spectrometry, we analyzed 304 lipids con ...[more]