Ontology highlight
ABSTRACT:
SUBMITTER: Lomash RM
PROVIDER: S-EPMC4567839 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Lomash Richa Madan RM Gu Xinglong X Youle Richard J RJ Lu Wei W Roche Katherine W KW
Cell reports 20150723 5
Membrane trafficking and spinogenesis contribute significantly to changes in synaptic strength during development and in various paradigms of synaptic plasticity. GTPases of the dynamin family are key players regulating membrane trafficking. Here, we identify a brain-specific dynamin family GTPase, neurolastin (RNF112/Znf179), with closest homology to atlastin. We demonstrate that neurolastin has functional GTPase and RING domains, making it a unique protein identified with this multi-enzymatic ...[more]