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Fusagerins A-F, New Alkaloids from the Fungus Fusarium sp.


ABSTRACT: Fusagerins A-F (1-6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3-6), were isolated from the crude extract of the fungus Fusarium sp., together with the known compound fungerin (7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1-6 were determined mainly by NMR experiments, and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism (ECD) calculations. Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and weak cytotoxicity against the T24 cells.

SUBMITTER: Wen H 

PROVIDER: S-EPMC4567992 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Fusagerins A-F, New Alkaloids from the Fungus Fusarium sp.

Wen Hao H   Li Yan Y   Liu Xingzhong X   Ye Wencai W   Yao Xinsheng X   Che Yongsheng Y  

Natural products and bioprospecting 20150801 4


Fusagerins A-F (1-6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3-6), were isolated from the crude extract of the fungus Fusarium sp., together with the known compound fungerin (7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1-6 were determined mainly by NMR experiments, and the absolute  ...[more]

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