Ontology highlight
ABSTRACT:
SUBMITTER: Wijeratne EM
PROVIDER: S-EPMC3896239 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Wijeratne E M Kithsiri EM He Hongping H Franzblau Scott G SG Hoffman Angela M AM Gunatilaka A A Leslie AA
Journal of natural products 20130930 10
Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations. ...[more]