Ontology highlight
ABSTRACT:
SUBMITTER: van Opijnen T
PROVIDER: S-EPMC4568079 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
van Opijnen Tim T Lazinski David W DW Camilli Andrew A
Current protocols in molecular biology 20140414
The lagging annotation of bacterial genomes and the inherent genetic complexity of many phenotypes is hindering the discovery of new drug targets and the development of new antimicrobial agents and vaccines. This unit presents Tn-seq, a method that has made it possible to quantitatively determine fitness for most genes in a microorganism and to screen for quantitative genetic interactions on a genome-wide scale and in a high-throughput fashion. Tn-seq can thus direct studies on the annotation of ...[more]