Ontology highlight
ABSTRACT:
SUBMITTER: Zakir TS
PROVIDER: S-EPMC8878391 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Zakir Tasnim Saifudin TS Meng Tao T Carmen Lee Ching Pei LCP Chu Justin Jang Hann JJH Lin Raymond Tzer Pin RTP Prabakaran Mookkan M
Viruses 20220124 2
The constant mutation of SARS-CoV-2 has led to the emergence of new variants, which call for urgent effective therapeutic interventions. The trimeric spike (S) protein of SARS-CoV-2 is highly immunogenic with the receptor-binding domain (RBD) that binds first to the cellular receptor angiotensin-converting enzyme 2 (ACE2) and is therefore the target of many neutralizing antibodies. In this study, we characterized a broadly neutralizing monoclonal antibody (mAb) 9G8, which shows potent neutraliza ...[more]