Ontology highlight
ABSTRACT:
SUBMITTER: Neeson PJ
PROVIDER: S-EPMC4570118 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Neeson Paul J PJ Hsu Andy K AK Chen Yin R YR Halse Heloise M HM Loh Joanna J Cordy Reece R Fielding Kate K Davis Joanne J Noske Josh J Davenport Alex J AJ Lindqvist-Gigg Camilla A CA Humphreys Robin R Tai Tsin T Prince H Miles HM Trapani Joseph A JA Smyth Mark J MJ Ritchie David S DS
Oncoimmunology 20150527 9
There is increasing evidence that some cancer therapies can promote tumor immunogenicity to boost the endogenous antitumor immune response. In this study, we used the novel combination of agonistic anti-TRAIL-R1 antibody (mapatumumab, Mapa) with low dose bortezomib (LDB) for this purpose. The combination induced profound myeloma cell apoptosis, greatly enhanced the uptake of myeloma cell apoptotic bodies by dendritic cell (DC) and induced anti-myeloma cytotoxicity by both CD8<sup>+</sup> T cells ...[more]