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Neoadjuvant therapy for gastric cancer: current evidence and future directions.

ABSTRACT: Although surgical resection remains the only potentially curative treatment for gastric cancer (GC), poor long-term outcomes with resection alone compel a multimodality approach to this disease. Multimodality strategies vary widely; while adjuvant approaches are typically favored in Asia and the United States (USA), a growing body of evidence supports neoadjuvant and/or perioperative strategies in locally advanced tumors. Neoadjuvant approaches are particularly attractive given the morbidity associated with surgical management of GC and the substantial risk of omission of adjuvant therapy. The specific advantages of chemoradiotherapy (CRT) compared to chemotherapy have not been well defined, particularly in the preoperative setting and trials aimed at determining the optimal elements and sequencing of therapy are underway. Future studies will also define the role of targeted and biologic therapies.

SUBMITTER: Newton AD

PROVIDER: S-EPMC4570921 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Neoadjuvant therapy for gastric cancer: current evidence and future directions.

Newton Andrew D AD Datta Jashodeep J Loaiza-Bonilla Arturo A Karakousis Giorgos C GC Roses Robert E RE

Journal of gastrointestinal oncology 20151001 5

Although surgical resection remains the only potentially curative treatment for gastric cancer (GC), poor long-term outcomes with resection alone compel a multimodality approach to this disease. Multimodality strategies vary widely; while adjuvant approaches are typically favored in Asia and the United States (USA), a growing body of evidence supports neoadjuvant and/or perioperative strategies in locally advanced tumors. Neoadjuvant approaches are particularly attractive given the morbidity ass ...[more]

PMID: 26487948

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