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Future directions of neoadjuvant therapy in pancreatic cancer.

ABSTRACT: Neoadjuvant therapy with conventional chemotherapies have visibly improved the prognosis of locally advanced pancreatic cancer (PCa). However, molecular targeted therapies that have provided durable responses in other tumor entities, have not yet found access into neoadjuvant therapy of PCa. In fact, due to the presence of the tumor burden serving as an antigen source for T cell priming, neoadjuvant chemotherapy may unleash a more potent antitumoral immune response than adjuvant or palliative chemotherapy.

SUBMITTER: Mota Reyes C

PROVIDER: S-EPMC7458337 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Future directions of neoadjuvant therapy in pancreatic cancer.

Mota Reyes Carmen C Yurteri Ümmügülsüm Ü Friess Helmut H Demir Ihsan Ekin IE

Oncoscience 20200514 7-8

Neoadjuvant therapy with conventional chemotherapies have visibly improved the prognosis of locally advanced pancreatic cancer (PCa). However, molecular targeted therapies that have provided durable responses in other tumor entities, have not yet found access into neoadjuvant therapy of PCa. In fact, due to the presence of the tumor burden serving as an antigen source for T cell priming, neoadjuvant chemotherapy may unleash a more potent antitumoral immune response than adjuvant or palliative ch ...[more]

PMID: 32923514

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