Ontology highlight
ABSTRACT:
SUBMITTER: Mohlke KL
PROVIDER: S-EPMC4572004 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Mohlke Karen L KL Boehnke Michael M
Human molecular genetics 20150709 R1
Genome-wide association (GWAS) and sequencing studies are providing new insights into the genetic basis of type 2 diabetes (T2D) and the inter-individual variation in glycemic traits, including levels of glucose, insulin, proinsulin and hemoglobin A1c (HbA1c). At the end of 2011, established loci (P < 5 × 10(-8)) totaled 55 for T2D and 32 for glycemic traits. Since then, most new loci have been detected by analyzing common [minor allele frequency (MAF)>0.05] variants in increasingly large sample ...[more]