Ontology highlight
ABSTRACT:
SUBMITTER: Pan W
PROVIDER: S-EPMC4572508 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Pan Wei W Kwak Il-Youp IY Wei Peng P
American journal of human genetics 20150625 1
In spite of the success of genome-wide association studies (GWASs), only a small proportion of heritability for each complex trait has been explained by identified genetic variants, mainly SNPs. Likely reasons include genetic heterogeneity (i.e., multiple causal genetic variants) and small effect sizes of causal variants, for which pathway analysis has been proposed as a promising alternative to the standard single-SNP-based analysis. A pathway contains a set of functionally related genes, each ...[more]