Ontology highlight
ABSTRACT:
SUBMITTER: Yang T
PROVIDER: S-EPMC6399020 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Yang Tianzhong T Chen Han H Tang Hongwei H Li Donghui D Wei Peng P
Statistics in medicine 20181120 7
As whole-exome/genome sequencing data become increasingly available in genetic epidemiology research consortia, there is emerging interest in testing the interactions between rare genetic variants and environmental exposures that modify the risk of complex diseases. However, testing rare-variant-based gene-by-environment interactions (GxE) is more challenging than testing the genetic main effects due to the difficulty in correctly estimating the latter under the null hypothesis of no GxE effects ...[more]