Ontology highlight
ABSTRACT:
SUBMITTER: Jiang L
PROVIDER: S-EPMC4572928 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Jiang Lingjuan L Wang Lu L Zhang Jihui J Liu Hao H Hong Bin B Tan Huarong H Niu Guoqing G
Scientific reports 20150915
Antimicrobial agents are urgently needed to tackle the growing threat of antibiotic-resistant pathogens. An important source of new antimicrobials is the large repertoire of cryptic gene clusters embedded in microbial genomes. Genome mining revealed a napsamycin/mureidomycin biosynthetic gene cluster in the chromosome of Streptomyces roseosporus NRRL 15998. The cryptic gene cluster was activated by constitutive expression of a foreign activator gene ssaA from sansanmycin biosynthetic gene cluste ...[more]