DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors.
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ABSTRACT:
SUBMITTER: Mazor T
PROVIDER: S-EPMC4573399 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors.
Mazor Tali T Pankov Aleksandr A Johnson Brett E BE Hong Chibo C Hamilton Emily G EG Bell Robert J A RJA Smirnov Ivan V IV Reis Gerald F GF Phillips Joanna J JJ Barnes Michael J MJ Idbaih Ahmed A Alentorn Agusti A Kloezeman Jenneke J JJ Lamfers Martine L M MLM Bollen Andrew W AW Taylor Barry S BS Molinaro Annette M AM Olshen Adam B AB Chang Susan M SM Song Jun S JS Costello Joseph F JF
Cancer cell 20150901 3
The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and sensitive to the microenvironment, prompting the question whether epigenetic information can similarly be used to discover tumor phylogeny. We examined the spatial and temporal dynamics of DNA methylation in a cohort of low-grade gliomas and their patient-matched recurrences. Genes transcriptionally upregulated th ...[more]
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