Ontology highlight
ABSTRACT:
SUBMITTER: Harms PW
PROVIDER: S-EPMC4573907 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Harms Paul William PW Vats Pankaj P Verhaegen Monique Elise ME Robinson Dan R DR Wu Yi-Mi YM Dhanasekaran Saravana Mohan SM Palanisamy Nallasivam N Siddiqui Javed J Cao Xuhong X Su Fengyun F Wang Rui R Xiao Hong H Kunju Lakshmi P LP Mehra Rohit R Tomlins Scott A SA Fullen Douglas Randall DR Bichakjian Christopher Keram CK Johnson Timothy M TM Dlugosz Andrzej Antoni AA Chinnaiyan Arul M AM
Cancer research 20150803 18
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-negative MCC is largely unexplored. Through our MI-ONCOSEQ precision oncology study, we performed integrative sequencing on two cases of MCPyV-negative MCC, as well as a validation cohort ...[more]