Ontology highlight
ABSTRACT:
SUBMITTER: Bionda N
PROVIDER: S-EPMC4573908 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20150806 14
Methods to access natural-product-like macrocyclic peptides can disclose new opportunities for the exploration of this important structural class for chemical biology and drug discovery applications. Here, the scope and mechanism of a novel strategy for directing the biosynthesis of thioether-bridged bicyclic peptides in bacterial cells was investigated. This method entails split intein-catalyzed head-to-tail cyclization of a ribosomally produced precursor peptide, combined with inter-side-chain ...[more]