Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi M
PROVIDER: S-EPMC10978974 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Communications chemistry 20240328 1
Bicyclic peptides exhibit improved metabolic stabilities and target specificities when compared to their linear or mono-cyclic counterparts; however, efficient and straightforward synthesis remains challenging due to their intricate architectures. Here, we present a highly selective and operationally simple one-pot chemoenzymatic tandem cyclization approach to synthesize bicyclic peptides with small to medium ring sizes. Penicillin-binding protein-type thioesterases (PBP-type TEs) efficiently cy ...[more]