Ontology highlight
ABSTRACT:
SUBMITTER: Jaszczak JS
PROVIDER: S-EPMC4574233 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Jaszczak Jacob S JS Wolpe Jacob B JB Dao Anh Q AQ Halme Adrian A
Genetics 20150616 4
Mechanisms that coordinate growth during development are essential for producing animals with proper organ proportion. Here we describe a pathway through which tissues communicate to coordinate growth. During Drosophila melanogaster larval development, damage to imaginal discs activates a regeneration checkpoint through expression of Dilp8. This both produces a delay in developmental timing and slows the growth of undamaged tissues, coordinating regeneration of the damaged tissue with developmen ...[more]