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Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.

ABSTRACT: Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGF?/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.

SUBMITTER: Upadhyay A

PROVIDER: S-EPMC7371420 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.

Upadhyay Ambuj A Peterson Aidan J AJ Kim Myung-Jun MJ O'Connor Michael B MB

eLife 20200707

Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin ( ...[more]

PMID: 32633716

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