Ontology highlight
ABSTRACT:
SUBMITTER: Ke J
PROVIDER: S-EPMC4575091 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ke Juntao J Lou Jiao J Chen Xueqin X Li Jiaoyuan J Liu Cheng C Gong Yajie Y Yang Yang Y Zhu Ying Y Zhang Yi Y Gong Jing J
PloS one 20150918 9
Large-scale genome-wide association studies (GWAS) have established chromosome 5q31.1 as a susceptibility locus for colorectal cancer (CRC), which was still lack of causal genetic variants. We searched potentially regulatory single nucleotide polymorphisms (SNPs) in the overlap region between linkage disequilibrium (LD) block of 5q31.1 and regulatory elements predicted by histone modifications, then tested their association with CRC via a case-control study. Among three candidate common variants ...[more]