Ontology highlight
ABSTRACT:
SUBMITTER: Nakashige TG
PROVIDER: S-EPMC4575267 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nakashige Toshiki G TG Zhang Bo B Krebs Carsten C Nolan Elizabeth M EM
Nature chemical biology 20150824 10
Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis of CP-treated growth medium establishes that CP reduces the concentrations of manganese, iron and zinc. Microbial growth studies reveal that iron depletion by CP contributes to the growth inhibition o ...[more]