Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC4575530 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Liu Shan S Jackson Andrew A Beloor Jagadish J Kumar Priti P Sutton Richard E RE
Human gene therapy 20150811 9
Despite nearly three decades of research, a safe and effective vaccine against human immunodeficiency virus type 1 (HIV-1) has yet to be achieved. More recently, the discovery of highly potent anti-gp160 broadly neutralizing antibodies (bNAbs) has garnered renewed interest in using antibody-based prophylactic and therapeutic approaches. Here, we encoded bNAbs in first-generation adenoviral (ADV) vectors, which have the distinctive features of a large coding capacity and ease of propagation. A si ...[more]