Ontology highlight
ABSTRACT:
SUBMITTER: Shih DM
PROVIDER: S-EPMC6356528 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Shih Diana M DM Meng Yonghong Y Sallam Tamer T Vergnes Laurent L Shu Michelle L ML Reue Karen K Tontonoz Peter P Fogelman Alan M AM Lusis Aldons J AJ Reddy Srinivasa T ST
Antioxidants (Basel, Switzerland) 20190111 1
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice are more susceptible to atherosclerosis. Furthermore, PON2 deficiency leads to impaired mitochondrial function. (2) Methods: In this study, we examined the susceptibility of PON2-def mice to diet-induced obesity. (3) Results: After feeding of an ...[more]