Ontology highlight
ABSTRACT:
SUBMITTER: Kranzusch PJ
PROVIDER: S-EPMC4575873 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Molecular cell 20150820 6
In humans, the cGAS-STING immunity pathway signals in response to cytosolic DNA via 2',3' cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed 2'-5' and 3'-5' phosphodiester bonds. Prokaryotes also produce CDNs, but these are exclusively 3' linked, and thus the evolutionary origins of human 2',3' cGAMP signaling are unknown. Here we illuminate the ancient origins of human cGAMP signaling by discovery of a functional cGAS-STING pathway in Nematostella vectensis, an anemone species ...[more]