Ontology highlight
ABSTRACT:
SUBMITTER: Carvalho L
PROVIDER: S-EPMC4576119 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Carvalho Luis L Martínez-García Marta M Pérez-Victoria Ignacio I Manzano José Ignacio JI Yardley Vanessa V Gamarro Francisco F Pérez-Victoria José M JM
Antimicrobial agents and chemotherapy 20150720 10
The protozoan parasite Trypanosoma brucei causes human African trypanosomiasis, or sleeping sickness, a neglected tropical disease that requires new, safer, and more effective treatments. Repurposing oral drugs could reduce both the time and cost involved in sleeping sickness drug discovery. Tafenoquine (TFQ) is an oral antimalarial drug belonging to the 8-aminoquinoline family which is currently in clinical phase III. We show here that TFQ efficiently kills different T. brucei spp. in the submi ...[more]