Ontology highlight
ABSTRACT:
SUBMITTER: Graca NA
PROVIDER: S-EPMC4808195 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20160325 4
Current treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives againstTrypanosoma brucei BNIPDiaminobutane (BNIPDabut), the most active of these compounds, showedin vitroinhibition in the single-unit nanomolar range, similar to the activity in the reference drug pentamidine, and presented low toxicity and adequate metabolic stability. Additionally, usin ...[more]