Ontology highlight
ABSTRACT:
SUBMITTER: Giles K
PROVIDER: S-EPMC4576665 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Giles Kurt K Berry David B DB Condello Carlo C Hawley Ronald C RC Gallardo-Godoy Alejandra A Bryant Clifford C Oehler Abby A Elepano Manuel M Bhardwaj Sumita S Patel Smita S Silber B Michael BM Guan Shenheng S DeArmond Stephen J SJ Renslo Adam R AR Prusiner Stanley B SB
The Journal of pharmacology and experimental therapeutics 20150729 1
Because no drug exists that halts or even slows any neurodegenerative disease, developing effective therapeutics for any prion disorder is urgent. We recently reported two compounds (IND24 and IND81) with the 2-aminothiazole (2-AMT) chemical scaffold that almost doubled the incubation times in scrapie prion-infected, wild-type (wt) FVB mice when given in a liquid diet. Remarkably, oral prophylactic treatment with IND24 beginning 14 days prior to intracerebral prion inoculation extended survival ...[more]