Ontology highlight
ABSTRACT:
SUBMITTER: Fuss JO
PROVIDER: S-EPMC4576882 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Fuss Jill O JO Tsai Chi-Lin CL Ishida Justin P JP Tainer John A JA
Biochimica et biophysica acta 20150202 6
Fe-S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism, DNA, and the RNA world. The double helix solved the mystery of DNA replication by base pairing for accurate copying. Yet, for genome stability necessary to life, the double helix has equally important implications for damage repair. Here we examine striking advances that uncover Fe-S cluster roles both in copying the genetic sequence by DNA polymerases and in crucial repair processes for genome maintenanc ...[more]