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New developments in the management of advanced melanoma - role of pembrolizumab.


ABSTRACT: Cancer immunotherapy is now recognized to be fundamental in modern oncology, because immune system recruitment may represent a powerful and innovative strategy in cancer therapy. Pembrolizumab, a highly selective humanized monoclonal antibody directly blocking the interaction between programmed cell death-1 expressed by tumor-associated T-cells and its ligand programmed cell death-L1 present on tumor and stromal cells, was recently approved by US Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma and disease progression upon ipilimumab and BRAF inhibitor. This review will focus on the clinical development and use of pembrolizumab in the clinical practice and in the management of advanced melanoma.

SUBMITTER: Improta G 

PROVIDER: S-EPMC4576895 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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New developments in the management of advanced melanoma - role of pembrolizumab.

Improta Giuseppina G   Leone Isabella I   Donia Marco M   Gieri Stefania S   Pelosi Giuseppe G   Fraggetta Filippo F  

OncoTargets and therapy 20150914


Cancer immunotherapy is now recognized to be fundamental in modern oncology, because immune system recruitment may represent a powerful and innovative strategy in cancer therapy. Pembrolizumab, a highly selective humanized monoclonal antibody directly blocking the interaction between programmed cell death-1 expressed by tumor-associated T-cells and its ligand programmed cell death-L1 present on tumor and stromal cells, was recently approved by US Food and Drug Administration for the treatment of  ...[more]

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