Ontology highlight
ABSTRACT:
SUBMITTER: Bettigole SE
PROVIDER: S-EPMC4577297 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bettigole Sarah E SE Lis Raphael R Adoro Stanley S Lee Ann-Hwee AH Spencer Lisa A LA Weller Peter F PF Glimcher Laurie H LH
Nature immunology 20150706 8
The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth cells, yet its function in granulocyte maturation has remained unknown. Here we discovered an unexpectedly selective and absolute requirement for XBP1 in eosinophil differentiation without an effect on the survival of basophils or neutrophils. Progenitors of myeloid cells and eosinophils selectively activated the endoribonuclease IRE1α and spliced Xbp1 mRNA without inducin ...[more]