Ontology highlight
ABSTRACT:
SUBMITTER: Salloum G
PROVIDER: S-EPMC6737911 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Journal of cell science 20190816 16
Macropinocytosis is an actin-dependent but clathrin-independent endocytic process by which cells nonselectively take up large aliquots of extracellular material. Macropinocytosis is used for immune surveillance by dendritic cells, as a route of infection by viruses and protozoa, and as a nutrient uptake pathway in tumor cells. In this study, we explore the role of class I phosphoinositide 3-kinases (PI3Ks) during ligand-stimulated macropinocytosis. We find that macropinocytosis in response to re ...[more]