Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B.
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ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC4577881 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B.
Journal of virology 20150722 19
We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 es ...[more]
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