An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics.
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ABSTRACT:
SUBMITTER: Wuo MG
PROVIDER: S-EPMC4577959 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics.
Wuo Michael G MG Mahon Andrew B AB Arora Paramjit S PS
Journal of the American Chemical Society 20150904 36
Coiled coils are a major motif in proteins and orchestrate multimerization of various complexes important for biological processes. Inhibition of coiled coil-mediated interactions has significant biomedical potential. However, general approaches that afford short peptides with defined coiled coil conformation remain elusive. We evaluated several strategies to stabilize minimal helical bundles, with the dimer motif as the initial focus. A stable dimeric scaffold was realized in a synthetic sequen ...[more]
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