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New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males.


ABSTRACT: BACKGROUND:Research has demonstrated an association between exposure to early life stress and an increased risk of psychiatric disorders in later life, in particular depression. However, the mechanism through which early life stress contributes to disease development remains unclear. Previous studies have reported an association between early life stress and altered methylation of the serotonin transporter gene (SLC6A4), a key candidate gene for several psychiatric disorders. These differences in methylation are influenced by sex and genetic variation in the SLC6A4-linked polymorphic region (5-HTTLPR). Furthermore, one study indicated that stress during pregnancy may induce methylation changes in SLC6A4 in the newborn. The present study is the first to investigate whether early life stress during pregnancy impacts on SLC6A4 methylation in newborns, taking into account the influence of genetic variation and sex. METHODS:Cord blood was obtained from newborns with high (n?=?45) or low (n?=?45) early life stress, defined as maternal stress during pregnancy. The effect on methylation of early life stress, 5-HTTLPR genotype, and sex was assessed at four cytosin-phosphate-guanine dinucleotide (CpG) sites in the promoter associated CpG island north shore (CpG 1 to 4). The epigenetic analyses focused on these CpG sites, since research has shown that CpG island shore methylation has functional consequences. RESULTS:Significant sex-specific methylation was observed, with females displaying higher methylation levels than males (p?

SUBMITTER: Dukal H 

PROVIDER: S-EPMC4579500 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males.

Dukal Helene H   Frank Josef J   Lang Maren M   Treutlein Jens J   Gilles Maria M   Wolf Isabell Ac IA   Krumm Bertram B   Massart Renaud R   Szyf Moshe M   Laucht Manfred M   Deuschle Michael M   Rietschel Marcella M   Witt Stephanie H SH  

Borderline personality disorder and emotion dysregulation 20150415


<h4>Background</h4>Research has demonstrated an association between exposure to early life stress and an increased risk of psychiatric disorders in later life, in particular depression. However, the mechanism through which early life stress contributes to disease development remains unclear. Previous studies have reported an association between early life stress and altered methylation of the serotonin transporter gene (SLC6A4), a key candidate gene for several psychiatric disorders. These diffe  ...[more]

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